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Oxamate, a pyruvate analog, competes for the active site of LDH, displaying antitumor activity in diverse cancer cell lines, such as gastric, medulloblastoma, cervical, liver, and non-small cell lung cancers

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RSL3 is known to interact with thioredoxin reductase 1 (Txnrd1) which also plays a role in DNA damage and oxidative stress 31

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